TfOH-catalyzed regioselective N2-alkylation of indazoles with diazo compounds

Author:

He Hangli12,Yan Jingyu2,Jin Jingru12,Yan Zhewei12,Yan Qiongjiao1,Wang Wei1ORCID,Jiang Haipeng1,Wang Haifeng12,Chen Fener134ORCID

Affiliation:

1. Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan 430205, China

2. School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China

3. Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China

4. Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs, Shanghai 200433, China

Abstract

A novel highly selective N2-alkylation of indazoles with diazo compounds is described in good to excellent yields with high regioselectivity (N2/N1 up to 100/0) and excellent functional group tolerance.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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