Shikonin derivatives as inhibitors of tyrosyl-tRNA synthetase: design, synthesis and biological evaluation-Reference-Cited by-同舟云学术

Shikonin derivatives as inhibitors of tyrosyl-tRNA synthetase: design, synthesis and biological evaluation

Published:2016 Issue:86 Volume:6 Page:83003-83010
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Qiu Han-Yue¹²³⁴⁵,Wang Peng-Fei¹²³⁴⁵,Wang Zi-Zhen¹²³⁴⁵,Luo Yue-Lin¹²³⁴⁵,Hu Dong-Qing¹²³⁴⁵,Qi Jin-Liang¹²³⁴⁵,Lu Gui-Hua¹²³⁴⁵,Pang Yan-Jun¹²³⁴⁵,Yang Rong-Wu¹²³⁴⁵,Zhu Hai-Liang¹²³⁴⁵,Wang Xiao-Ming¹²³⁴⁵^ORCID,Yang Yong-Hua¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Pharmaceutical Biotechnology

2. NJU-NJFU Joint Institute of Plant Molecular Biology

3. Nanjing University

4. Nanjing 210023

5. China

Abstract

A series of novel tyrosyl-tRNA synthetase inhibitors was designed and synthesized as anti-bacteria agents based on natural product shikonin and in silico scaffold modification strategy.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA17742E

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