Cheminformatic analysis of natural product-based drugs and chemical probes-Reference-Cited by-同舟云学术

Cheminformatic analysis of natural product-based drugs and chemical probes

Published:2022 Issue:1 Volume:39 Page:20-32
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Stone Samantha¹,Newman David J.²^ORCID,Colletti Steven L.³,Tan Derek S.¹⁴^ORCID

Affiliation:

1. Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York 10021, USA

2. NIH Special Volunteer, Wayne, PA 19087, USA

3. Zymergen, Inc., 430 E 29th St, New York 10016, USA

4. Tri-Institutional Research Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York 10021, USA

Abstract

Cheminformatic analyses illustrate that drugs from natural product-based and synthetic origins have distinctive structural and physicochemical features. These drugs also cluster by biosynthetic origin and, to some extent, by therapeutic class.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NP/D1NP00039J

Reference46 articles.

1. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

2. Cheminformatic comparison of approved drugs from natural product versus synthetic origins

3. Structure-based drug design: aiming for a perfect fit

4. DNA-Encoded Library Screening as Core Platform Technology in Drug Discovery: Its Synthetic Method Development and Applications in DEL Synthesis

5. Applications of chemogenomic library screening in drug discovery

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