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A systematic exploration of the effects of flexibility and basicity on sigma (σ) receptor binding in a series of substituted diamines

  • Published:2016 Issue:39 Volume:14 Page:9388-9405
  • ISSN:1477-0520
  • Container-title:Organic & Biomolecular Chemistry
  • language:en
  • Short-container-title:Org. Biomol. Chem.

Author:

Conroy Trent1234,Manohar Madhura1234,Gong Yu1234,Wilkinson Shane M.1234,Webster Michael1234,Lieberman Brian P.5678,Banister Samuel D.9108,Reekie Tristan A.1234,Mach Robert H.5678,Rendina Louis M.1234,Kassiou Michael1234

Affiliation:

1. School of Chemistry

2. The University of Sydney

3. Sydney

4. Australia

5. Department of Radiology

6. University of Pennsylvania School of Medicine

7. Philadelphia

8. USA

9. Department of Radiation Oncology

10. Stanford University School of Medicine

Abstract

Investigating amide and open chain piperazine analogues to target the sigma 1 receptor to fight neurological disorders.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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