Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram-Reference-Cited by-同舟云学术

Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram

Published:2021 Issue:7 Volume:12 Page:1174-1186
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Camacho-Hernandez Gisela Andrea¹²³⁴⁵^ORCID,Casiraghi Andrea¹²³⁴⁵^ORCID,Rudin Deborah⁶⁷⁸⁹¹⁰^ORCID,Luethi Dino⁶⁷⁸⁹¹⁰^ORCID,Ku Therese C.¹²³⁴⁵,Guthrie Daryl A.¹²³⁴⁵,Straniero Valentina¹¹¹²¹³¹⁴^ORCID,Valoti Ermanno¹¹¹²¹³¹⁴,Schütz Gerhard J.¹⁵¹⁶¹⁰,Sitte Harald H.⁶⁷⁸⁹¹⁰^ORCID,Newman Amy Hauck¹²³⁴⁵^ORCID

Affiliation:

1. Medicinal Chemistry Section

2. Molecular Targets and Medications Discovery Branch

3. National Institutes of Drug Abuse – Intramural Research Program

4. Baltimore

5. USA

6. Institute of Pharmacology

7. Center for Physiology and Pharmacology

8. Medical University of Vienna

9. Vienna

10. Austria

11. Department of Pharmaceutical Sciences

12. University of Milan

13. Milan

14. Italy

15. Institute of Applied Physics

16. 1060 Vienna

Abstract

A nisoxetine-based fluorescent probe, 6, has been synthesized that can be used to visualize the norepinephrine transporter (NET) in NET-expressing HEK293 cells at low nanomolar concentrations.

Funder

National Institute on Drug Abuse

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00072A

Reference31 articles.

1. SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

2. The solute carrier 6 family of transporters