Catalytic asymmetric multiple dearomatizations of phenols enabled by a cascade 1,8-addition and Diels

Catalytic asymmetric multiple dearomatizations of phenols enabled by a cascade 1,8-addition and Diels–Alder reaction

Published:2020 Issue:3 Volume:11 Page:671-676
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Xihong¹²³⁴⁵,Zhang Jingying¹²³⁴⁵,Bai Lutao¹²³⁴⁵,Wang Linqing¹²³⁴⁵,Yang Dongxu¹²³⁴⁵,Wang Rui¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province

2. Institute of Drug Design & Synthesis

3. School of Basic Medical Sciences

4. Lanzhou University

5. Lanzhou 730000

Abstract

The first chiral phosphoric acid catalyzed asymmetric multiple dearomatizations of phenols for the synthesis of bridged polycyclic compounds are reported.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC05320D

Reference87 articles.

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3. Transition-Metal-Catalyzed Asymmetric Allylic Dearomatization Reactions

4. Recent advances in dearomatization of heteroaromatic compounds

5. Advances in dearomatization strategies of indoles

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