The effects of cis and trans butenedioic acid on the physicochemical behavior of lumefantrine-Reference-Cited by-同舟云学术

The effects of cis and trans butenedioic acid on the physicochemical behavior of lumefantrine

Published:2022 Issue:1 Volume:24 Page:156-168
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Tomar Devendrasingh¹,Lodagekar Anurag¹,Gunnam Anilkumar²^ORCID,Allu Suryanarayana²^ORCID,Chavan Rahul B.¹,Tharkar Minakshi³^ORCID,Ajithkumar T. G.³,Nangia Ashwini K.²³^ORCID,Shastri Nalini R.¹^ORCID

Affiliation:

1. Solid-State Pharmaceutical Research Group (SSPRG), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500 037, India

2. School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, Gachibowli Central University P.O., Hyderabad 500 046, India

3. CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India

Abstract

A study of the differences in the effects of cis (maleic acid) and trans (fumaric acid) isomers of butenedioic acid on the crystallinity, amorphous nature, and pharmaceutical behaviour of the antimalarial drug lumefantrine is provided.

Funder

Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CE/D0CE01709D

Reference48 articles.

1. Organic acids as co-formers for co-amorphous systems – Influence of variation in molar ratio on the physicochemical properties of the co-amorphous systems

2. Powder grinding preparation of co-amorphous β-azelnidipine and maleic acid combination: Molecular interactions and physicochemical properties