Hydrazone-modulated peptides for efficient gene transfection-Reference-Cited by-同舟云学术

Hydrazone-modulated peptides for efficient gene transfection

Published:2017 Issue:23 Volume:5 Page:4426-4434
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Louzao Iria¹²³⁴⁵,García-Fandiño Rebeca¹²³⁴⁵,Montenegro Javier¹²³⁴⁵^ORCID

Affiliation:

1. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS)

2. Departamento de Química Orgánica

3. Universidade de Santiago de Compostela

4. 15782 Santiago de Compostela

5. Spain

Abstract

The synthetic potential of dynamic bond formation is introduced for the delivery of plasmid DNA by modulated amphiphilic peptides. The synthetic advantage of these dynamic bonds allowed the identification of improved reagents (better efficiency and lower toxicity) for plasmid transfection assays in human HeLa cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2017/TB/C7TB00179G

Reference48 articles.

1. Overcoming Gene-Delivery Hurdles: Physiological Considerations for Nonviral Vectors

2. Therapeutic genome editing: prospects and challenges

3. Non-viral vectors for gene-based therapy

4. Gene therapy finds its niche

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