Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity-Reference-Cited by-同舟云学术

Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity

Published:2024 Issue:14 Volume:12 Page:3445-3452
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Ortega-Caballero Fernando¹²^ORCID,Santana-Armas María L.³,Tros de Ilarduya Conchita³^ORCID,Di Giorgio Christophe⁴,Tripier Raphäel⁵^ORCID,Le Bris Nathalie⁵^ORCID,Ollier Cedric⁵^ORCID,Ortiz Mellet Carmen¹^ORCID,García Fernández José M.⁶^ORCID,Jiménez Blanco José L.¹^ORCID,Méndez-Ardoy Alejandro¹⁶^ORCID

Affiliation:

1. Department of Organic Chemistry, Faculty of Chemistry, University of Seville, c/Profesor García González 1, Sevilla 41012, Spain

2. Department of Organic Chemistry, Higher Polytechnic School, University of Seville, c/Virgen de África 7, Sevilla 41011, Spain

3. Department of Pharmaceutical Sciences, School of Pharmacy and Nutrition, University of Navarra, Pamplona 31080, Spain

4. Institut de Chimie Nice, UMR 7272, Université Côte d’Azur, 28 Avenue de Valrose, Nice 06108, France

5. Université de Brest, UMR CNRS 6521 CEMCA, 6 Avenue Victor le Gorgeu, Brest 29238, France

6. Instituto de Investigaciones Químicas (IIQ), CSIC –, Universidad de Sevilla, Avda. Américo Vespucio 49, Sevilla 41092, Spain

Abstract

A novel family of precision-engineered gene vectors with well-defined structures built on trehalose and trehalose-based macrocycles (cyclotrehalans) comprising linear or cyclic polyamine heads have been synthesized by click chemistry reactions.

Funder

H2020 Marie Skłodowska-Curie Actions

Agencia Estatal de Investigación

European Cooperation in Science and Technology

European Regional Development Fund

Ministerio de Ciencia e Innovación

European Observation Network for Territorial Development and Cohesion

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D3TB02889E

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5. Ongoing Clinical Trials of Nonviral siRNA Therapeutics

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