Colchicine derivatives with potent anticancer activity and reduced P-glycoprotein induction liability-Reference-Cited by-同舟云学术

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Colchicine derivatives with potent anticancer activity and reduced P-glycoprotein induction liability

Published:2015 Issue:20 Volume:13 Page:5674-5689
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Singh Baljinder¹²³⁴⁵,Kumar Ashok⁵²³⁴⁶,Joshi Prashant⁵²³⁴⁷,Guru Santosh K.⁶²³⁴,Kumar Suresh⁵²³⁴⁶,Wani Zahoor A.⁶²³⁴,Mahajan Girish⁶²³⁴,Hussain Aashiq⁶²³⁴,Qazi Asif Khurshid⁶²³⁴,Kumar Ajay⁶²³⁴,Bharate Sonali S.⁸²³⁴,Gupta Bishan D.¹²³⁴,Sharma Parduman R.⁶²³⁴,Hamid Abid⁵²³⁴⁶,Saxena Ajit K.⁵²³⁴⁶,Mondhe Dilip M.⁵²³⁴⁶,Bhushan Shashi⁵²³⁴⁶,Bharate Sandip B.⁵²³⁴⁷,Vishwakarma Ram A.¹²³⁴⁵

Affiliation:

1. Natural Product Chemistry Division

2. CSIR-Indian Institute of Integrative Medicine

3. Jammu 180001

4. India

5. Academy of Scientific & Innovative Research (AcSIR)

6. Cancer Pharmacology Division

7. Medicinal Chemistry Division

8. Preformulation Laboratory

Abstract

Colchicine derivatives with reduced P-gp induction liability have been identified.

Funder

Council of Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00406C

Reference58 articles.

1. Colchicine in clinical medicine. A guide for internists

2. Colchicine today

3. Colchicine Update: 2008

4. P-Glycoprotein-Mediated Colchicine Resistance in Different Cell Lines Correlates with the Effects of Colchicine on P-Glycoprotein Conformation

5. Colchicine biotransformation by human liver microsomes

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