Synthesis and Biological Evaluation of Colchicine─Aryl/Alkyl Amine Hybrids as Potential Noncytotoxic Cholinesterase Inhibitors: Identification of SBN-284 as a Dual Inhibitor of Cholinesterases and NLRP3 Inflammasome-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of Colchicine─Aryl/Alkyl Amine Hybrids as Potential Noncytotoxic Cholinesterase Inhibitors: Identification of SBN-284 as a Dual Inhibitor of Cholinesterases and NLRP3 Inflammasome

Published:2024-07-26 Issue:15 Volume:15 Page:2779-2794
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Reddy Chilakala Nagarjuna¹²,Nuthakki Vijay K.¹²^ORCID,Sharma Ankita¹²,Malik Sumera²³,Tabassum Misbah²³,Kumar Rajesh²³,Choudhary Sushil²³,Iqbal Fiza²³,Tufail Ziya²³,Mondhe Dilip M.²³,Kumar Ajay²³^ORCID,Bharate Sandip B.¹²⁴^ORCID

Affiliation:

1. Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India

2. Academy of Scientific & Innovative Research (AcSIR), Ghaziabad 201002, India

3. Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India

4. Department of Natural Products & Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India

Funder

Council of Scientific and Industrial Research, India

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.4c00153

Reference56 articles.

1. Challenges and hopes for Alzheimer’s disease

2. Inhibiting the Inflammasome: A Chemical Perspective

3. The NLRP3 Inflammasome Pathway: A Review of Mechanisms and Inhibitors for the Treatment of Inflammatory Diseases

4. The NLRP3 inflammasome: molecular activation and regulation to therapeutics

5. Why Are the Majority of Active Compounds in the CNS Domain Natural Products? A Critical Analysis

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