Synthesis of fused-tetrahydropyrimidines: one-pot methylenation–cyclization utilizing two molecules of CO2-Reference-Cited by-同舟云学术

Synthesis of fused-tetrahydropyrimidines: one-pot methylenation–cyclization utilizing two molecules of CO2

Published:2020 Issue:35 Volume:18 Page:6881-6888
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhao Yulei¹²³⁴^ORCID,Guo Xuqiang¹²³⁴,Du Yulan¹²³⁴,Shi Xinrui¹²³⁴,Yan Shina¹²³⁴,Liu Yunlin¹⁵⁶⁴^ORCID,You Jinmao¹²³⁴⁷^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering

2. Qufu Normal University

3. Qufu

4. China

5. Guangzhou University

6. Guangzhou

7. Northwest Institute of Plateau Biology

Abstract

A methylenation–cyclization reaction employing cyclic enaminones with primary aromatic amines and two molecules of CO₂ to furnish fused-tetrahydropyrimidines has been developed.

Funder

Natural Science Foundation of Shandong Province

Qufu Normal University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01504K

Reference61 articles.

1. A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

2. Synthesis of New Nonclassical Acridines, Quinolines, and Quinazolines Derived from Dimedone for Biological Evaluation

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4. Tricyclic 3,4-dihydropyrimidine-2-thione derivatives as potent TRPA1 antagonists

5. Efficient Synthesis of a Series of Novel Octahydroquinazoline-5-ones via a Simple on-Water Urea-Catalyzed Chemoselective Five-Component Reaction

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