Peptide epitope-imprinted polymer microarrays for selective protein recognition. Application for SARS-CoV-2 RBD protein

Author:

Bognár Zsófia1ORCID,Supala Eszter1ORCID,Yarman Aysu2,Zhang Xiaorong2,Bier Frank F.2,Scheller Frieder W.2,Gyurcsányi Róbert E.1ORCID

Affiliation:

1. BME “Lendület” Chemical Nanosensors Research Group, Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellért tér 4, 1111 Budapest, Hungary

2. Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476 Potsdam OT Golm, Germany

Abstract

We introduce highly affine epitope-imprinted polymer-based microarrays for selective protein detection by surface plasmon resonance imaging as shown through the selective recognition of the receptor binding domain of SARS-CoV-2 spike protein.

Funder

Nemzeti Kutatási Fejlesztési és Innovációs Hivatal

Bundesministerium für Bildung und Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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