Stimuli-responsive hydrogel microcapsules for the amplified detection of microRNAs

Author:

Chang Wen-Hsin1,Lee Yi-Fang1,Liu Yen-Wenn1,Willner Itamar2ORCID,Liao Wei-Ching13ORCID

Affiliation:

1. Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan

2. Institute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

3. Center for Advanced Pharmaceutics and Drug Delivery Research, National Yang Ming Chiao Tung University, Taipei 112, Taiwan

Abstract

A method for the synthesis of stimuli-responsive QDs-loaded DNA hydrogel microcapsules is demonstrated. The functionality of miRNA-responsive switches in the shell of microcapsules enables the microcapsules to sense the disease-associated miRNAs.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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