Non-enzymatic synthesis of <i>C</i>-methylated fluostatins: discovery and reaction mechanism-Reference-Cited by-同舟云学术

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Non-enzymatic synthesis of C-methylated fluostatins: discovery and reaction mechanism

Published:2024 Issue:6 Volume:22 Page:1152-1156
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

De Bidhan Chandra¹²,Yang Chunfang¹²^ORCID,Huang Chunshuai¹,Zhang Changsheng¹²^ORCID,Zhang Wenjun¹²^ORCID

Affiliation:

1. Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou 510301, China

2. University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China

Abstract

A non-enzymatic method to synthesize C-methylated Fluostatins by using DMSO to methylate C(sp2)–H bonds under mild conditions without any catalysts is described here. A mechanism for this reaction was proposed.

Funder

Chinese Academy of Sciences

National Natural Science Foundation of China

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D3OB01920A

Reference22 articles.

1. Installing the “magic methyl” – C–H methylation in synthesis

2. The Methylation Effect in Medicinal Chemistry

3. Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

4. S-Adenosyl-Methionine-Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications

5. S-Adenosylmethionine: more than just a methyl donor

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