Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging-Reference-Cited by-同舟云学术

Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging

Published:2014 Issue:20 Volume:12 Page:3271-3281
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mountford Simon J.¹²³,Liu Mengjie¹²³,Zhang Lei⁴⁵⁶⁷,Groenen Marleen⁸⁹¹⁰¹¹¹²,Herzog Herbert⁴⁵⁶⁷,Holliday Nicholas D.⁸⁹¹⁰¹¹¹²,Thompson Philip E.¹²³

Affiliation:

1. Medicinal Chemistry

2. Monash Institute of Pharmaceutical Sciences

3. Parkville, Australia

4. Neuroscience Research Program

5. Garvan Institute of Medical Research

6. St. Vincent's Hospital

7. Darlinghurst, Australia

8. Cell Signalling Research Group

9. School of Life Sciences

10. University of Nottingham

11. Queen's Medical Centre

12. Nottingham NG7 2UH, UK

Abstract

The potent Y₁receptor antagonist, 1229U91 has an unusual cyclic dimer structure. We have developed three new routes to the synthesis of analogues. Such variants, including fluorescent conjugates, show potent Y₁antagonism.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00176A

Reference46 articles.

1. Neuropeptide Y: complete amino acid sequence of the brain peptide.

2. Central nervous system pharmacology of neuropeptide Y

3. Neuropeptide Y and peptide YY: major modulators of gastrointestinal blood flow and function

4. Y-receptor subtypes—how many more?

5. Molecular characterization of the ligand-receptor interaction of the neuropeptide Y family

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