Heterodimeric Analogues of the Potent Y1R Antagonist 1229U91, Lacking One of the Pharmacophoric C-Terminal Structures, Retain Potent Y1R Affinity and Show Improved Selectivity over Y4R-Reference-Cited by-同舟云学术

Heterodimeric Analogues of the Potent Y1R Antagonist 1229U91, Lacking One of the Pharmacophoric C-Terminal Structures, Retain Potent Y1R Affinity and Show Improved Selectivity over Y4R

Published:2020-05-04 Issue:10 Volume:63 Page:5274-5286
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Richardson Rachel R.¹²,Groenen Marleen²,Liu Mengjie¹,Mountford Simon J.¹,Briddon Stephen J.²,Holliday Nicholas D.²^ORCID,Thompson Philip E.¹^ORCID

Affiliation:

1. Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia

2. Institute of Cell Signalling, School of Biomedical Sciences, Queen’s Medical Centre, University of Nottingham, Nottingham NG7 2UH, U.K.

Funder

Monash University

University of Nottingham

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00027

Reference57 articles.

1. Central nervous system pharmacology of neuropeptide Y

2. Therapeutic potential of neuropeptide Y (NPY) receptor ligands

3. The Role of Neuropeptide Y in Cardiovascular Health and Disease

4. Neuroendocrine peptide mechanisms controlling intestinal epithelial function

5. Y-receptor subtypes—how many more?

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