Controlled delivery of a protein tyrosine phosphatase inhibitor, SHP099, using cyclodextrin-mediated host–guest interactions in polyelectrolyte multilayer films for cancer therapy
Author:
Affiliation:
1. School of Engineering
2. Brown University
3. Providence
4. USA
5. Center for Biomedical Engineering
6. Department of Orthopaedics
7. Warren Alpert Medical School
8. Rhode Island Hospital
Abstract
Controlled delivery of a potent anticancer drug, SHP099, after supramolecular complexation into a versatile multilayer film.
Funder
National Institute of General Medical Sciences
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA03864D
Reference46 articles.
1. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
2. SHP2 sails from physiology to pathology
3. Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase
4. Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors
5. Dual Allosteric Inhibition of SHP2 Phosphatase
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