Complementary isonitrile-based multicomponent reactions for the synthesis of diversified cytotoxic hemiasterlin analogues

Author:

Lesma Giordano1234,Bassanini Ivan1234,Bortolozzi Roberta5674,Colletto Chiara1234,Bai Ruoli89101112,Hamel Ernest89101112,Meneghetti Fiorella1314154,Rainoldi Giulia1234,Stucchi Mattia1234,Sacchetti Alessandro1621734,Silvani Alessandra1234,Viola Giampietro5674

Affiliation:

1. Università di Milano

2. Dipartimento di Chimica

3. Milano

4. Italy

5. Università degli Studi di Padova

6. Dipartimento di Salute della Donna e del Bambino

7. Padova

8. Screening Technologies Branch

9. Developmental Therapeutics Program

10. Division of Cancer Treatment and Diagnosis

11. National Cancer Institute

12. Frederick National Laboratory for Cancer Research

13. Dipartimento di Scienze Farmaceutiche

14. Università degli Studi di Milano

15. 20133 Milano

16. Politecnico di Milano

17. Materiali ed Ing. Chimica ‘Giulio Natta’

Abstract

A multicomponent strategy proved to be suitable for the concise and convergent generation of hemiasterlin derivatives, also including non-peptidic analogues.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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