To rebound or dissociate? This is the mechanistic question in C–H hydroxylation by heme and nonheme metal

To rebound or dissociate? This is the mechanistic question in C–H hydroxylation by heme and nonheme metal–oxo complexes

Published:2016 Issue:5 Volume:45 Page:1197-1210
ISSN:0306-0012
Container-title:Chemical Society Reviews
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Cho Kyung-Bin¹²³⁴,Hirao Hajime⁵⁶⁷⁸⁹,Shaik Sason¹⁰¹¹¹²¹³,Nam Wonwoo¹²³⁴

Affiliation:

1. Department of Chemistry and Nano Science

2. Ewha Womans University

3. Seoul 03760

4. Korea

5. Division of Chemistry and Biological Chemistry

6. School of Physical and Mathematical Sciences

7. Nanyang Technological University

8. Singapore 637371

9. Republic of Singapore

10. Institute of Chemistry and The Lise Meitner-Minerva Center for Computational Quantum Chemistry

11. The Hebrew University of Jerusalem

12. 91904 Jerusalem

13. Israel

Abstract

Metal–oxo species can perform hydroxylation reactions via the rebound mechanism, but this review focuses on the cases where dissociative non-rebound mechanism is shown to dominate, with an emphasis on theoretical calculations.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CS/C5CS00566C

Reference50 articles.

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3. Key elements of the chemistry of cytochrome P-450: The oxygen rebound mechanism

4. Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate

5. Heme-Containing Oxygenases

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