Conjugation of bone grafts with NO-delivery dinitrosyl iron complexes promotes synergistic osteogenesis and angiogenesis in rat calvaria bone defects

Author:

Chang Shih-Hao123,Hsiao Hui-Yi345ORCID,Chen Yi-Hong6,Cheng Ming-Huei34,Liu Jia-Wei34,Huang Hsiao-Jo13,Chou Yu-Ting7,Amer Tarik Abdelkareem Mostafa7,Vijayaraghavan Priya8,Palanisamy Sathyadevi6,Wang Yun-Ming79ORCID,Lu Tsai-Te61011ORCID

Affiliation:

1. Department of Periodontics, Linkou Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan

2. Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan 33302, Taiwan

3. Center of Tissue Engineering, Linkuo Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan

4. Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan

5. Department of Biomedical Sciences, Chang Gung University, Taoyuan 33302, Taiwan

6. Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan

7. Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, College of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan

8. Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan

9. Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan

10. Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan

11. Department of Chemistry, Chung Yuan Christian University, Taoyuan 32023, Taiwan

Abstract

Through conjugation of osteoconductive bone graft materials with biomimetic dinitrosyl iron complexes (DNICs), spatiotemporal control over NO delivery activates synergistic osteogenesis and angiogenesis for the treatment of rat calvaria bone defects.

Funder

Ministry of Science and Technology, Taiwan

National Science and Technology Council

National Tsing Hua University

Chang Gung Medical Foundation

Chang Gung Memorial Hospital

Ministry of Education

Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital

National Taiwan Normal University

Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University

Society for Experimental Mechanics

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3