pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism-Reference-Cited by-同舟云学术

pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism

Published:2018 Issue:47 Volume:16 Page:9165-9170
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Xie Xinqiang¹²³⁴⁵^ORCID,Cane David E.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Box H

3. Brown University

4. Providence

5. USA

Abstract

PKS dehydratases utilize a one-base mechanism.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB02637H

Reference35 articles.

1. D. A. Hopwood , Methods in Enzymology. Complex enzymes in microbial natural product biosynthesis, part B: polyketides, aminocoumarins and carbohydrates , Academic Press , United States , 2009

2. The structural biology of biosynthetic megaenzymes

3. Assembly Line Polyketide Synthases: Mechanistic Insights and Unsolved Problems

4. Computational identification and analysis of orphan assembly-line polyketide synthases

5. Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

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