Characterization of bispecific antigen-binding biotherapeutic fragmentation sites using microfluidic capillary electrophoresis coupled to mass spectrometry (mCZE-MS)

Abstract

Microfluidic capillary zone electrophoresis coupled to mass spectrometry enables improved throughput, resolution, and sensitivity in characterization of 12–40 kDa bispecific antigen-binding biotherapeutic fragments compared to traditional methods.