Multi-component bioresponsive nanoparticles for synchronous delivery of docetaxel and TUBB3 siRNA to lung cancer cells-Reference-Cited by-同舟云学术

Multi-component bioresponsive nanoparticles for synchronous delivery of docetaxel and TUBB3 siRNA to lung cancer cells

Published:2021 Issue:26 Volume:13 Page:11414-11426
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Conte Claudia¹²^ORCID,Monteiro Patrícia F.¹,Gurnani Pratik¹^ORCID,Stolnik Snow¹,Ungaro Francesca²^ORCID,Quaglia Fabiana²^ORCID,Clarke Philip³,Grabowska Anna³,Kavallaris Maria⁴⁵⁶,Alexander Cameron¹^ORCID

Affiliation:

1. Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, NG7 2RD, UK

2. Drug Delivery Laboratory, Department of Pharmacy, University of Napoli Federico II, 80131 Napoli, Italy

3. The BioDiscovery Institute and Faculty of Medicine & Health Sciences, University of Nottingham, NG7 2RD, UK

4. Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, NSW 2052, Australia

5. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and Australian Centre for NanoMedicine, UNSW Sydney, NSW 2052, Australia

6. School of Women's and Children's Health, Faculty of Medicine, UNSW Sydney, NSW, Australia 2052

Abstract

Redox-responsive NPs, delivering DTX in combination with TUBB3 siRNA, increased DTX activity in lung cancer (LC) cells. After local administration in LC mice models, NPs were retained into the lungs thus exerting high siRNA silencing efficacy.

Funder

Associazione Italiana per la Ricerca sul Cancro

European Commission

National Health and Medical Research Council

Australian Research Council

Engineering and Physical Sciences Research Council

Cancer Australia

Royal Society

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science