Redox‐Responsive Polymeric Nanoparticle for Nucleic Acid Delivery and Cancer Therapy: Progress, Opportunities, and Challenges

Author:

Xu Lei123,Cao Yuan123,Xu Ya123,Li Rong4,Xu Xiaoding1234ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong‐Hong Kong Joint Laboratory for RNA Medicine Medical Research Center Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou 510120 P. R. China

2. Guangzhou Key Laboratory of Medical Nanomaterials Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou 510120 P. R. China

3. Nanhai Translational Innovation Center of Precision Immunology Sun Yat‐Sen Memorial Hospital Foshan 528200 P. R. China

4. The Second Affiliated Hospital Hengyang Medical School University of South China Hengyang 421001 P. R. China

Abstract

AbstractCancer development and progression of cancer are closely associated with the activation of oncogenes and loss of tumor suppressor genes. Nucleic acid drugs (e.g., siRNA, mRNA, and DNA) are widely used for cancer therapy due to their specific ability to regulate the expression of any cancer‐associated genes. However, nucleic acid drugs are negatively charged biomacromolecules that are susceptible to serum nucleases and cannot cross cell membrane. Therefore, specific delivery tools are required to facilitate the intracellular delivery of nucleic acid drugs. In the past few decades, a variety of nanoparticles (NPs) are designed and developed for nucleic acid delivery and cancer therapy. In particular, the polymeric NPs in response to the abnormal redox status in cancer cells have garnered much more attention as their potential in redox‐triggered nanostructure dissociation and rapid intracellular release of nucleic acid drugs. In this review, the important genes or signaling pathways regulating the abnormal redox status in cancer cells are briefly introduced and the recent development of redox‐responsive NPs for nucleic acid delivery and cancer therapy is systemically summarized. The future development of NPs‐mediated nucleic acid delivery and their challenges in clinical translation are also discussed.

Funder

National Natural Science Foundation of China

Guangdong Provincial Department of Science and Technology

Key Research and Development Program of Hunan Province of China

Publisher

Wiley

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering,Biotechnology

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