Study on the hemodynamic effects of different pulsatile working modes of a rotary blood pump using a microfluidic platform that realizes in vitro cell culture effectively

Author:

Liang Lixue12,Wang Xueying3,Chen Dong1,Sethu Palaniappan4,Giridharan Guruprasad A.5,Wang Yanxia6,Wang Yu17ORCID,Qin Kai-Rong17ORCID

Affiliation:

1. Institute of Cardio-Cerebrovascular Medicine, Central Hospital of Dalian University of Technology, Dalian 116024, Liaoning Province, P. R. China

2. School of Mechanical Engineering, Dalian University of Technology, Dalian 116024, Liaoning Province, P. R. China

3. School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian 116024, Liaoning Province, P. R. China

4. Division of Cardiovascular Disease, Department of Medicine, School of Medicine and Department of Biomedical Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, AL, USA

5. Department of Bioengineering, University of Louisville, Louisville, KY, USA

6. School of Rehabilitation Medicine, Shandong Second Medical University, Weifang 261053, Shandong Province, P. R. China

7. School of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian 116024, Liaoning Province, P. R. China

Abstract

The best pulsation frequency mode of the RBP would be one that changes every 2–3 times of the cardiac cycle. The proposed in vitro microfluidic model could provide an effective platform to select the best working mode of the RBP for heart failure.

Funder

Fundamental Research Funds for the Central Universities

Foundation for the National Institutes of Health

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

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