Development of in vitro microfluidic models to study endothelial responses to pulsatility with different mechanical circulatory support devices

Author:

Wang Xueying1,Liang Lixue2,Giridharan Guruprasad A.3,Sethu Palaniappan4,Wang Yanxia5,Qin Kai-rong6ORCID,Qu Peng6,Wang Yu6ORCID

Affiliation:

1. School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian 116024, Liaoning Province, P. R. China

2. School of Mechanical Engineering, Dalian University of Technology, Dalian 116024, Liaoning Province, P. R. China

3. Department of Bioengineering, University of Louisville, Louisville, KY 40292, USA

4. Department of Biomedical Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA

5. School of Rehabilitation Medicine, Shandong Second Medical University, Weifang 261053, Shandong Province, P. R. China

6. School of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian 116024, Liaoning Province, P. R. China

Abstract

CPD can replace CFVAD with pulsatile working modes to a certain extent to treat non-severe HF. The proposed in vitro microfluidic models provided scientific basis for selecting different mechanical circulatory support devices.

Funder

Natural Science Foundation of Shandong Province

Foundation for the National Institutes of Health

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

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