Electrophilic ring fluorination of 3,5-disubstituted pyrazoles: application to the formal synthesis of a neprilysin inhibitor key intermediate-Reference-Cited by-同舟云学术

Electrophilic ring fluorination of 3,5-disubstituted pyrazoles: application to the formal synthesis of a neprilysin inhibitor key intermediate

Published:2020 Issue:47 Volume:44 Page:20535-20543
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Westermeyer Anne¹²³⁴⁵,Guillamot Gérard⁶⁷⁸,Phansavath Phannarath¹²³⁴⁵,Ratovelomanana-Vidal Virginie¹²³⁴⁵^ORCID

Affiliation:

1. PSL University

2. Chimie ParisTech-CNRS

3. Institute of Chemistry for Life & Health Sciences

4. CSB2D Team

5. 75005 Paris

6. SEQENS

7. 78440 Porcheville

8. France

Abstract

The access to a new family of unusual 4-fluorinated pyrazoles bearing acetal moities at the 3- or 5-position has been achieved by electrophilic fluorination using Selectfluor® with yields up to 67%.

Funder

Ministère de l’Enseignement supérieur, de la Recherche et de l'Innovation

Centre National de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NJ/D0NJ05222A

Reference26 articles.

1. Structure–Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development

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3. Synthesis, Acaricidal Activity, and Structure–Activity Relationships of Pyrazolyl Acrylonitrile Derivatives

4. Understanding organofluorine chemistry. An introduction to the C–F bond

5. Fluorine in medicinal chemistry

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