Biodegradable self-assembly micelles significantly enhanced the solubility, biological stability and in vivo antitumor efficacy of Hexylselen-Reference-Cited by-同舟云学术

Biodegradable self-assembly micelles significantly enhanced the solubility, biological stability and in vivo antitumor efficacy of Hexylselen

Published:2021 Issue:6 Volume:2 Page:1669-1681
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Fang Jinzhang¹^ORCID,Chen Zhao¹^ORCID,Song Jun¹^ORCID,Li Jinxiu¹^ORCID,Han Yunying¹^ORCID,Hou Wei¹^ORCID,Wang Wenxi¹^ORCID,Ruan Benfang H.¹^ORCID

Affiliation:

1. IDD & CB, College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China

Abstract

Soluplus increased the aqueous solubility of Hexylselen (CPD-3B) by about 3000-fold forming nano-sized micelles, significantly enhanced the stability in blood and liver microsomes and improved the in vivo bioavailability and antitumor efficacy.

Funder

Zhejiang University of Technology

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CB/D1CB00089F

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