Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors

Published:2012-11-30 Issue:23 Volume:55 Page:10551-10563
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shukla Krupa,Ferraris Dana V.,Thomas Ajit G.,Stathis Marigo,Duvall Bridget,Delahanty Greg,Alt Jesse,Rais Rana,Rojas Camilo,Gao Ping¹,Xiang Yan²,Dang Chi V.²,Slusher Barbara S.,Tsukamoto Takashi

Affiliation:

1. School of Life Science, University of Science and Technology of China, Hefei 230027, China

2. Abramson Family Cancer Research Institute, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301191p

Reference28 articles.

1. Regulation of Glutaminase Activity and Glutamine Metabolism

2. Brick by brick: metabolism and tumor cell growth

3. Glutaminase: A Hot Spot For Regulation Of Cancer Cell Metabolism?

4. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

5. Glutamate production by HIV-1 infected human macrophage is blocked by the inhibition of glutaminase

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