Design, synthesis, anticancer activity, molecular docking and ADME studies of novel methylsulfonyl indole-benzimidazoles in comparison with ethylsulfonyl counterparts
Author:
Affiliation:
1. Department of Pharmaceutical Chemistry
2. Faculty of Pharmacy
3. Ankara University
4. Ankara
5. Turkey
6. Interdisciplinary Program in Neuroscience
7. Bilkent University
8. Department of Molecular Biology and Genetics
Abstract
Specific sidechain modifications on the indole-benzimidazole scaffold play fundamental roles for determining molecule's affinity against ERα and its anti-cancer activity.
Funder
Türkiye Bilimsel ve Teknolojik Araştirma Kurumu
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,General Chemistry,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ01019K
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5. New piperidine derivative DTPEP acts as dual-acting anti-breast cancer agent by targeting ERα and downregulating PI3K/Akt-PKCα leading to caspase-dependent apoptosis
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