New piperidine derivative DTPEP acts as dual-acting anti-breast cancer agent by targeting ERα and downregulating PI3K/Akt-PKCα leading to caspase-dependent apoptosis

Author:

Arun A.1,Ansari M.I.2,Popli P.1,Jaiswal S.2,Mishra A.K.3,Dwivedi A.14,Hajela K.2,Konwar R.14ORCID

Affiliation:

1. Endocrinology Division; CSIR-Central Drug Research Institute; Lucknow UP India

2. Medicinal and Process Chemistry Division; CSIR-Central Drug Research Institute; Lucknow UP India

3. Department of Endocrine Surgery; King George's Medical University; Lucknow UP India

4. Academy of Scientific and Innovative Research (AcSIR), CSIR-Central Drug Research Institute Campus; Lucknow UP India

Funder

Council of Scientific and Industrial Research

Indian Council of Medical Research

Publisher

Wiley

Subject

Cell Biology,General Medicine

Reference55 articles.

1. Estrogen and cancer;Liang;Annu Rev Physiol,2013

2. Estrogen receptor modulators and down regulators: optimal use in postmenopausal women with breast cancer;Baumann;Drugs,2007

3. Tamoxifen

4. Stimulatory effects of 4-hydroxytamoxifen on proliferation of human endometrial adenocarcinoma cells (Ishikawa line);Anzai;Cancer Res,1989

5. Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells;Gundimeda;J Biol Chem,1996

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