Design, synthesis, and anti-proliferative evaluation of 1H-1,2,3-triazole grafted tetrahydro-β-carboline-chalcone/ferrocenylchalcone conjugates in estrogen responsive and triple negative breast cancer cells

Author:

Sharma Bharvi1234,Gu Liang5678,Pillay Ruvesh Pascal5678,Cele Nosipho910118,Awolade Paul910118ORCID,Singh Parvesh910118,Kaur Mandeep5678,Kumar Vipan1234ORCID

Affiliation:

1. Department of Chemistry

2. Guru Nanak Dev University

3. Amritsar-143005

4. India

5. School of Molecular and Cell Biology

6. University of the Witwatersrand

7. Johannesburg

8. South Africa

9. School of Chemistry and Physics

10. University of KwaZulu-Natal

11. Durban

Abstract

A series of 1H-1,2,3 triazole grafted tetrahydro-β-carboline-chalcone/ferrocenylchalcone conjugates were synthesized and in vitro evaluated against estrogen responsive (MCF-7) and triple negative (MDA-MB-231) breast cancer cells.

Funder

Council of Scientific and Industrial Research

National Research Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Reference31 articles.

1. American Cancer Society, Cancer facts and figures 2019

2. https://healthcare-in-europe.com/en/news/40-of-women-with-breast-cancer-live-in-asia.html

3. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

4. Epidemiology of breast cancer in Indian women

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