Re-engineering natural products to engage new biological targets
Author:
Affiliation:
1. Department of Chemistry
2. Institute for Genomic Biology
3. Cancer Center at Illinois
4. University of Illinois
5. Urbana-Champaign
Abstract
Incorporating natural product-like features within small-molecule screening collections is of great interest. We highlight an emerging strategy that achieves this goal by using abundant natural products as starting points for compound construction.
Funder
National Institutes of Health
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/NP/D0NP00059K
Reference97 articles.
1. High throughput screening in drug discovery
2. High Throughput Screening for Drug Discovery: Continually Transitioning into New Technology
3. The Future of High-Throughput Screening
4. Origin and evolution of high throughput screening
5. Hit and lead generation: beyond high-throughput screening
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