Mechanistic perspective and functional activity of insulin in amylin aggregation-Reference-Cited by-同舟云学术

Mechanistic perspective and functional activity of insulin in amylin aggregation

Published:2018 Issue:18 Volume:9 Page:4244-4252
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Baram Michal¹²³⁴⁵,Gilead Sharon⁶⁷⁸⁴,Gazit Ehud⁶⁷⁸⁴⁹^ORCID,Miller Yifat¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Ben-Gurion University of the Negev

3. Be'er Sheva 84105

4. Israel

5. The Ilse Katz Institute for Nanoscale Science & Technology

6. Department of Molecular Microbiology and Biotechnology

7. Tel Aviv University

8. Tel Aviv 69978

9. Department of Materials Science and Engineering

Abstract

This work provides the first-ever complete atomic model of insulin–amylin aggregates, identifying the specific interactions that stabilize the insulin–amylin complex.

Funder

Israel Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC00481A

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2. Insulins today and beyond

3. Reactive oxygen species extend insect life span using components of the insulin-signaling pathway

4. Insulin B chain 9–23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3 + T regs

5. Mechanisms linking obesity to insulin resistance and type 2 diabetes

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