Insulin B chain 9–23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3 + T regs-Reference-Cited by-同舟云学术

Insulin B chain 9–23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3 + T regs

Published:2015-05-27 Issue:289 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Akbarpour Mahzad¹²,Goudy Kevin S.¹,Cantore Alessio¹,Russo Fabio¹,Sanvito Francesca³,Naldini Luigi¹²,Annoni Andrea¹,Roncarolo Maria Grazia¹²⁴

Affiliation:

1. San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.

2. Vita-Salute San Raffaele University, Milan 20132, Italy.

3. Pathology Unit, Department of Oncology, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.

4. Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA.

Abstract

Hepatocyte-targeted InsB 9–23 gene transfer protects from type 1 diabetes by inducing antigen-specific regulatory T cells.

Funder

JDRF

Fondazione Telethon

Italian Ministry of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference71 articles.

1. Insulin-Dependent Diabetes Mellitus

2. THE NOD MOUSE: A Model of Immune Dysregulation

3. CD4+ T Cells from Glutamic Acid Decarboxylase (GAD)65-specific T Cell Receptor Transgenic Mice Are Not Diabetogenic and Can Delay Diabetes Transfer

4. Islet-Specific Glucose-6-Phosphatase Catalytic Subunit-Related Protein-Reactive CD4+ T Cells in Human Subjects

5. Chromogranin A is an autoantigen in type 1 diabetes

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