Synthesis of 1,3,4-trisubstituted pyrrolidines as meropenem adjuvants targeting New Delhi metallo-β-lactamase-Reference-Cited by-同舟云学术

Synthesis of 1,3,4-trisubstituted pyrrolidines as meropenem adjuvants targeting New Delhi metallo-β-lactamase

Published:2021 Issue:7 Volume:45 Page:3515-3534
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Jin Wen Bin¹²³⁴⁵,Xu Chen¹²³⁴⁶,Qi Xiao Lin¹²³⁴,Zeng Ping¹²³⁴,Gao Wei¹²³⁴,Lai Ki Hon¹²³⁴,Chiou Jiachi¹²³⁴,Chan Edward W. C.¹²³⁴,Leung Yun-Chung¹²³⁴,Chan Tak Hang¹²³⁴⁷,Wong Kwok-Yin¹²³⁴^ORCID,Chen Sheng⁸⁹¹⁰³⁴,Chan Kin-Fai¹²³⁴^ORCID

Affiliation:

1. State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology

2. The Hong Kong Polytechnic University

3. Kowloon

4. China

5. Faculty of Chinese Materia Medica

6. Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre

7. Department of Chemistry

8. Department of Infectious Diseases and Public Health

9. Jockey Club College of Veterinary Medicine and Life Sciences

10. City University of Hong Kong

Abstract

A promising NDM-1 inhibitor was discovered by the construction of pyrrolidine library via boric acid-catalyzed 1,3-dipolar cycloaddition and cell-based screens.

Funder

Health and Medical Research Fund

Research Grants Council, University Grants Committee

Innovation and Technology Commission

Hong Kong Polytechnic University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D0NJ06090A

Reference49 articles.