Affiliation:
1. Key Laboratory of External Drug Delivery System and Preparation Technology in Universities of Yunnan, and Faculty of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, Yunnan, China
Abstract
Oridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.
Funder
National Natural Science Foundation of China
Yunnan Key Research and Development Program
State Key Laboratory of Molecular Biology
Natural Science Foundation of Yunnan Province
Publisher
Royal Society of Chemistry (RSC)