Effective design of PEGylated polyion complex (PIC) nanoparticles for enhancing PIC internalisation in cells utilising block copolymer combinations with mismatched ionic chain lengths-Reference-Cited by-同舟云学术

Effective design of PEGylated polyion complex (PIC) nanoparticles for enhancing PIC internalisation in cells utilising block copolymer combinations with mismatched ionic chain lengths

Published:2024 Issue:7 Volume:12 Page:1826-1836
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Aulia Fadlina¹,Matsuba Hiroaki¹,Adachi Shoya¹,Yamada Takumi¹,Nakase Ikuhiko²,Nii Teruki³,Mori Takeshi³⁴^ORCID,Katayama Yoshiki³⁴⁵⁶⁷^ORCID,Kishimura Akihiro³⁴⁵^ORCID

Affiliation:

1. Graduate School of Systems Life Sciences, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan

2. Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, 1-1, Gakuen-cho, Naka-ku, Sakai-shi, Osaka 599-8531, Japan

3. Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan

4. Center for Future Chemistry, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan

5. Center for Molecular Systems, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan

6. Center for Advanced Medical Open Innovation, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan

7. Department of Biomedical Engineering, Chung Yuan Christian University, 200 Chung Pei Rd., Chung Li, Taiwan, 32023, ROC

Abstract

Design factors of PEGylated polyion complex (PIC) nanoparticles, particularly PIC vesicles, were examined regarding polyion chain matching, domain crosslinking, and chemical modification of charged units, to modulate mammalian cell-PIC interaction.

Funder

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D3TB02049E

Reference48 articles.

1. Effect of pegylation on pharmaceuticals

2. Uptake of liposomes by cultured mouse bone marrow macrophages: influence of liposome composition and size

3. Surface Functionalization of Nanoparticles with Polyethylene Glycol: Effects on Protein Adsorption and Cellular Uptake

4. PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles

5. The Polyethyleneglycol Dilemma: Advantage and Disadvantage of PEGylation of Liposomes for Systemic Genes and Nucleic Acids Delivery to Tumors