DNA interactions and in vitro anticancer evaluations of pyridine-benzimidazole-based Cu complexes-Reference-Cited by-同舟云学术

DNA interactions and in vitro anticancer evaluations of pyridine-benzimidazole-based Cu complexes

Published:2018 Issue:2 Volume:9 Page:337-343
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Hu Jiyong¹²³⁴,Liao Chunli⁵²³⁴,Mao Ruina⁶⁷⁸⁴,Zhang Junshuai¹²³⁴,Zhao Jin'an¹²³⁴^ORCID,Gu Zhenzhen¹²³⁴

Affiliation:

1. College of Material and Chemical Engineering

2. Henan University of Urban Construction

3. Pingdingshan 467036

4. PR China

5. College of Life Science and Engineering

6. College of Chemistry and Molecular Engineering

7. Zhengzhou University

8. Zhengzhou

Abstract

Complex 1 with in vitro cytotoxicity strongly binds to DNA, activates ROS generation, causes mitochondria dysfunction, and induces cellular apoptosis.

Funder

National Natural Science Foundation of China

Henan University

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C7MD00462A

Reference28 articles.

1. The role of carrier ligands of platinum(ii) anticancer complexes in the protein recognition of Pt–DNA adducts

2. Update on metal N-heterocyclic carbene complexes as potential anti-tumor metallodrugs

3. Linking the future of anticancer metal-complexes to the therapy of tumour metastases

4. Ligand effect and cooperative role of metal ions on the DNA cleavage efficiency of mono and binuclear Cu(II) macrocyclic ligands complexes

5. Next-Generation Metal Anticancer Complexes: Multitargeting via Redox Modulation

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