The role of carrier ligands of platinum(ii) anticancer complexes in the protein recognition of Pt

The role of carrier ligands of platinum(ii) anticancer complexes in the protein recognition of Pt–DNA adducts

Published:2015 Issue:74 Volume:51 Page:14064-14067
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

He Yafeng¹²³⁴⁵,Yuan Jian¹²³⁴⁵,Qiao Yuchen¹²³⁴⁵,Wang Dan¹²³⁴⁵,Chen Weizhong¹²³⁴⁵,Liu Xichun¹²³⁴⁵,Chen Hao¹²³⁴⁵,Guo Zijian¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Coordination Chemistry

2. Coordination Chemistry Institute

3. State Key Laboratory of Analytical Chemistry for Life Science

4. School of Chemistry and Chemical Engineering

5. Collaborative Innovation Centre of Chemistry for Life Sciences

Abstract

A series of DNA probes has been constructed to systematically investigate the influence of carrier ligands on the interaction of Pt-DNA adducts with damage recognition proteins.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C5CC05257B

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5. Increased gene-specific repair of cisplatin interstrand cross-links in cisplatin-resistant human ovarian cancer cell lines.

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