Structure–activity relationships of valine, tert-leucine, and phenylalanine amino acid-derived synthetic cannabinoid receptor agonists related to ADB-BUTINACA, APP-BUTINACA, and ADB-P7AICA

Author:

Sparkes Eric12ORCID,Cairns Elizabeth A.23ORCID,Kevin Richard C.23ORCID,Lai Felcia4,Grafinger Katharina Elisabeth5ORCID,Chen Shuli6,Deventer Marie H.7ORCID,Ellison Ross8,Boyd Rochelle12,Martin Lewis J.23ORCID,McGregor Iain S.23,Gerona Roy R.8,Hibbs David E.4ORCID,Auwärter Volker5,Glass Michelle6,Stove Christophe7ORCID,Banister Samuel D.12ORCID

Affiliation:

1. School of Chemistry, The University of Sydney, NSW 2006, Australia

2. The Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney, NSW 2050, Australia

3. School of Psychology, The University of Sydney, NSW 2050, Australia

4. School of Pharmacy, The University of Sydney, NSW 2006, Australia

5. Institute of Forensic Medicine, Forensic Toxicology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany

6. Department of Pharmacology and Toxicology, University of Otago, Dunedin 9016, New Zealand

7. Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium

8. Clinical Toxicology and Environmental Biomonitoring Laboratory, University of California, San Francisco, CA 94143, USA

Abstract

Synthetic cannabinoid receptor agonists (SCRAs) remain one the most prevalent classes of new psychoactive substances (NPS) worldwide, and examples are generally poorly characterised at the time of first detection.

Funder

Fonds Wetenschappelijk Onderzoek

National Health and Medical Research Council

University of Sydney

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

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