Cu(ii)-TACN complexes selectively induce antitumor activity in HepG-2 cells via DNA damage and mitochondrial-ROS-mediated apoptosis-Reference-Cited by-同舟云学术

Cu(ii)-TACN complexes selectively induce antitumor activity in HepG-2 cells via DNA damage and mitochondrial-ROS-mediated apoptosis

Published:2020 Issue:1 Volume:49 Page:114-123
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Liu Ming¹²³⁴⁵,Song Xue-Qing⁶⁷⁸⁹⁵,Wu Yuan-Di¹²³⁴⁵,Qian Jing¹²³⁴⁵^ORCID,Xu Jing-Yuan⁶⁷⁸⁹⁵^ORCID

Affiliation:

1. Tianjin Key Laboratory of Structure and Performance for Functional Molecules; Key Laboratory of Inorganic-Organic Hybrid Functional Material Chemistry

2. Ministry of Education; College of Chemistry

3. Tianjin Normal University

4. Tianjin 300387

5. China

6. Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics)

7. School of Pharmacy

8. Tianjin Medical University

9. Tianjin 300070

Abstract

A novel 1,4,7-triazacyclononane derivative (btacn), and its related copper complexes, Cu(btacn)Cl₂ and [Cu(btacn)₂]·(ClO₄)₂, exhibit potent anti-proliferation activity towards HepG-2 and HeLa cells, but low cytotoxicity towards normal cell lines.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Tianjin City

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/DT/C9DT03641E

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