The molecular mechanism behind the stabilization of insulin by choline and geranate (CAGE) ionic liquids – computational insights into oral insulin drug formulation-Reference-Cited by-同舟云学术

The molecular mechanism behind the stabilization of insulin by choline and geranate (CAGE) ionic liquids – computational insights into oral insulin drug formulation

Published:2021 Issue:44 Volume:23 Page:25298-25307
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Palanisamy Kandhan¹^ORCID,Prakash Muthuramalingam¹^ORCID

Affiliation:

1. Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur 603203, Chennai, Tamil Nadu, India

Abstract

The water-mediated H-bonding interactions and electrostatic effects of geranate ions can enhance the stability of insulin at 0.30–0.50 mole fraction of CAGE ILs.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D1CP03349B

Reference64 articles.

1. Insulin dimer dissociation in aqueous solution: A computational study of free energy landscape and evolving microscopic structure along the reaction pathway

2. Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering

3. Dynamical control by water at a molecular level in protein dimer association and dissociation

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