Hypoxia-stimulated mesenchymal stem cell-derived exosomes loaded by adhesive hydrogel for effective angiogenic treatment of spinal cord injury-Reference-Cited by-同舟云学术

Hypoxia-stimulated mesenchymal stem cell-derived exosomes loaded by adhesive hydrogel for effective angiogenic treatment of spinal cord injury

Published:2022 Issue:7 Volume:10 Page:1803-1811
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Mu Jiafu¹,Li Liming¹²,Wu Jiahe¹³,Huang Tianchen¹,Zhang Yu¹,Cao Jian¹,Ma Teng¹,Chen Jiachen¹,Zhang Chenyang¹,Zhang Xunqi¹,Lu Tinghao¹,Kong Xianglei⁴,Sun Jihong⁴,Gao Jianqing¹⁵^ORCID

Affiliation:

1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

2. Pilot National Laboratory for Marine Science and Technology, Qingdao 266137, China

3. Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China

4. Department of Radiology Sir Run Run Shaw Hospital, School of Medicine Zhejiang University, Hangzhou 310016, China

5. Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou 310058, China

Abstract

Implantation of hypoxia-stimulated mesenchymal stem cell-derived exosome encapsulated in an adhesive hydrogel induced pro-angiogenic spinal cord repair through transporting HIF-1α and upregulating vascular endothelial growth factor expression in recipient endothelial cells.

Funder

National Key Research and Development Program of China Stem Cell and Translational Research

Zhejiang Provincial Ten Thousand Plan for Young Top Talents

Primary Research and Development Plan of Zhejiang Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D1BM01722E

Reference51 articles.