A Functionalized Scaffold Facilitates Neurites Extension for Spinal Cord Injury Therapy

Author:

Huang Tianchen12,Mu Jiafu1,Wu Jiahe13,Cao Jian1,Zhang Xunqi1,Guo Jing1,Zhu Manning1,Ma Teng1,Jiang Xinchi1,Feng Shiqing45,Gao Jianqing126ORCID

Affiliation:

1. College of Pharmaceutical Sciences Zhejiang University Hangzhou Zhejiang 310058 P. R. China

2. Hangzhou Institute of Innovative Medicine College of Pharmaceutical Sciences Zhejiang University Hangzhou Zhejiang 310058 P. R. China

3. Department of Clinical Pharmacology Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province Affiliated Hangzhou First People's Hospital Westlake University School of Medicine Hangzhou Zhejiang 310006 P. R. China

4. Department of Orthopaedics Tianjin Medical University General Hospital Tianjin Key Laboratory of Spine and Spinal Cord Tianjin 300052 P. R. China

5. The Second Hospital of Shandong University Cheeloo College of Medicine Shandong University Jinan 250012 P. R. China

6. Jinhua Institute of Zhejiang University Jinhua Zhejiang 321002 P. R. China

Abstract

AbstractScaffolds have garnered considerable attention for enhancing neural repairment for spinal cord injury (SCI) treatment. Both microstructural features and biochemical modifications play pivotal roles in influencing the interaction of cells with the scaffold, thereby affecting tissue regeneration. Here, a scaffold is designed with spiral structure and gradient peptide modification (GS) specifically for SCI treatment. The spiral structure provides crucial support and space, while the gradient peptide isoleucine‐lysine‐valine‐alanine‐valine (IKVAV) modification imparts directional guidance for neuronal and axonal extension. GS scaffold shows a significant nerve extension induction effect through its interlayer gap and gradient peptide density to dorsal root ganglia in vitro, while in vivo studies reveal its substantial promotion for functional recovery and neural repair. Additionally, the GS scaffold displays impressive drug‐loading capacity, mesenchymal stem cell‐derived exosomes can be efficiently loaded into the GS scaffold and delivered to the injury site, thereby synergistically promoting SCI repair. Overall, the GS scaffold can serve as a versatile platform and present a promising multifunctional approach for SCI treatment.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China Stem Cell and Translational Research

Publisher

Wiley

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