Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC)-Reference-Cited by-同舟云学术

Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC)

Published:2022 Issue:29 Volume:58 Page:4635-4638
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Chotitumnavee Jiranan¹²,Yamashita Yasunobu¹,Takahashi Yukari²,Takada Yuri¹^ORCID,Iida Tetsuya¹²,Oba Makoto²^ORCID,Itoh Yukihiro¹²^ORCID,Suzuki Takayoshi¹²

Affiliation:

1. SANKEN, Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan

2. Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-cho, Sakyo-ku, Kyoto 606-0823, Japan

Abstract

We report a first-in-class PROTAC that induces HDAC8-selective degradation versus other HDACs and potently inhibits the growth of Jurkat cells.

Funder

Naito Foundation

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Osaka University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC00272H

Reference45 articles.

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2. Targeted protein degradation: expanding the toolbox

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