Experimental validation of in silico target predictions on synergistic protein targets-Reference-Cited by-同舟云学术

Experimental validation of in silico target predictions on synergistic protein targets

Published:2013 Issue:1 Volume:4 Page:278-288
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Cortes-Ciriano Isidro¹²³⁴⁵,Koutsoukas Alexios⁶⁷⁸⁹¹⁰,Abian Olga¹²³⁴⁵,Glen Robert C.⁶⁷⁸⁹¹⁰,Velazquez-Campoy Adrian¹²³⁴⁵,Bender Andreas⁶⁷⁸⁹¹⁰

Affiliation:

1. Institute of Biocomputation and Physics of Complex Systems (BIFI)

2. Unidad Asociada IQFR-CSIC-BIFI, and Department of Biochemistry and Molecular and Cellular Biology

3. Universidad de Zaragoza

4. Zaragoza

5. Spain

6. Unilever Centre for Molecular Science Informatics

7. Department of Chemistry

8. University of Cambridge

9. Cambridge CB2 1EW

10. UK

Abstract

Two relatively recent trends have become apparent in current early stage drug discovery settings: firstly, a revival of phenotypic screening strategies and secondly, the increasing acceptance that some drugs work by modulating multiple targets in parallel (‘multi-target drugs’).

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2013/MD/C2MD20286G

Reference64 articles.

1. Unfinished business: target-based drug discovery

2. Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds

3. How were new medicines discovered?

4. Finding the target after screening the phenotype

5. Target identification and validation through genetics

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Identification of metabolic pathways involved in the biotransformation of eslicarbazepine acetate using UPLC-MS/MS, human microsomal enzymes and in silico studies;Journal of King Saud University - Science;2021-03

2. Improving the prediction of organism-level toxicity through integration of chemical, protein target and cytotoxicity qHTS data;Toxicology Research;2016

3. Advantages and Challenges of Phenotypic Screens;Journal of Biomolecular Screening;2015-10-12

4. Proteochemometric modelling coupled to in silico target prediction: an integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules;Journal of Cheminformatics;2015-04-15

5. Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts;Future Medicinal Chemistry;2014-12