Dynamic light scattering and transmission electron microscopy in drug delivery: a roadmap for correct characterization of nanoparticles and interpretation of results

Author:

Filippov Sergey K.12ORCID,Khusnutdinov Ramil3ORCID,Murmiliuk Anastasiia4ORCID,Inam Wali2,Zakharova Lucia Ya.5ORCID,Zhang Hongbo26ORCID,Khutoryanskiy Vitaliy V.1ORCID

Affiliation:

1. School of Pharmacy, University of Reading, Whiteknights, RG6 6DX Reading, UK

2. Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, 20520 Turku, Finland

3. Institute of Pharmacy, Kazan State Medical University, 16 Fatykh Amirkhan, 420126 Kazan, Russian Federation

4. Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 00 Prague 2, Czech Republic

5. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Str., 420088 Kazan, Russian Federation

6. Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland

Abstract

In this focus article, we provide a scrutinizing analysis of transmission electron microscopy and dynamic light scattering as the two common methods to study the sizes of nanoparticles with focus on the application in pharmaceutics and drug delivery.

Funder

Royal Society

Russian Science Foundation

Leverhulme Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrical and Electronic Engineering,Process Chemistry and Technology,Mechanics of Materials,General Materials Science

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