A homogeneous high-DAR antibody–drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides-Reference-Cited by-同舟云学术

A homogeneous high-DAR antibody–drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides

Published:2022 Issue:11 Volume:13 Page:3147-3160
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zacharias Neelie¹,Podust Vladimir N.²,Kajihara Kimberly K.¹,Leipold Douglas¹^ORCID,Del Rosario Geoffrey¹,Thayer Desiree²,Dong Emily¹,Paluch Maciej¹,Fischer David¹,Zheng Kai¹,Lei Corinna¹,He Jintang¹,Ng Carl¹,Su Dian¹,Liu Luna¹,Masih Shabkhaiz¹,Sawyer William¹,Tinianow Jeff¹,Marik Jan¹,Yip Victor¹,Li Guangmin¹,Chuh Josefa¹,Morisaki J. Hiroshi¹,Park Summer¹,Zheng Bing¹,Hernandez-Barry Hilda¹,Loyet Kelly M.¹,Xu Min¹,Kozak Katherine R.¹,Phillips Gail Lewis¹,Shen Ben-Quan¹,Wu Cong¹^ORCID,Xu Keyang¹,Yu Shang-Fan¹,Kamath Amrita¹,Rowntree Rebecca K.¹,Reilly Dorothea¹,Pillow Thomas¹,Polson Andrew¹,Schellenberger Volker²,Hazenbos Wouter L. W.¹,Sadowsky Jack¹^ORCID

Affiliation:

1. Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA

2. Amunix Pharmaceuticals, Inc., 2 Tower Place, South San Francisco, CA 94080, USA

Abstract

Efficiency of targeted cell delivery of small molecules was enhanced in cells and animals via a novel well-defined bioconjugation platform combining site-specific antibody conjugation and XTEN polypeptides to enable high payload loading.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC05243H

Reference41 articles.

1. Unlocking the potential of antibody–drug conjugates for cancer therapy

2. Antibody-Drug Conjugates: Functional Principles and Applications in Oncology and Beyond

3. An Insight into FDA Approved Antibody-Drug Conjugates for Cancer Therapy

4. Selective Intracellular Delivery of Dexamethasone into Activated Endothelial Cells Using an E-Selectin-Directed Immunoconjugate

5. Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates

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